Keap1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comKeap1 Polyclonal Antibody for Mouse(Mus musculus)

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Keap1 (Gene name),

Kelch-like ECH-associated protein 1 (Protein name ), KEAP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Keap1(Inrf2;Kiaa0132);

Protein name:

Kelch-like ECH-associated protein 1;

Alternative:

Cytosolic inhibitor of Nrf2(INrf2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1.

Function:

Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Subcellular Location:

Cytoplasm Nucleus Shuttles between cytoplasm and nucleus.

Protein Attributes:

Sequence length:

624

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

624:

RSGVGVAVTM | EPCRKQIDQQ | NCTC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9Z2X8

KEGG:

mmu:50868

STRING:

10090.ENSMUSP00000062467

String:

Q9Z2X8

Pfam:

PF07707

UniGene:

Mm.248266

Uniprot:

Q9Z2X8

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ELISA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

E2835r

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96T

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ELISA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

E2835h

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96T

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ELISA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

E2835p

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

E2835m

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96T

CLIA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

U2835r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

U2835p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

U2835h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Kelch-like ECH-associated protein 1

Cat.:

U2835m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Kelch-like ECH-associated protein 1

Cat.:

P2835Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Kelch-like ECH-associated protein 1

Cat.:

P2835Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Kelch-like ECH-associated protein 1

Cat.:

P2835Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Kelch-like ECH-associated protein 1

Protein for Mouse Kelch-like ECH-associated protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain."
Itoh K. , Wakabayashi N. , Katoh Y. , Ishii T. , Igarashi K. , Engel J.D. , Yamamoto M.
Genes Dev.13:76-86(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
tissue: Embryo.
2.

"Mouse INrf2 gene structure."
Dhakshinamoorthy S. , Jaiswal A.K.
Submitted (2001-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: C57BL/6.
3.

"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Fetal brain.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Bone marrow.
tissue: Corpora quadrigemina.
tissue: Dendritic cell.
tissue: Liver.
tissue: Lung.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
6.

"Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression."
McMahon M. , Itoh K. , Yamamoto M. , Hayes J.D.
J. Biol. Chem.278:21592-21600(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein."
Strachan G.D. , Morgan K.L. , Otis L.L. , Caltagarone J. , Gittis A. , Bowser R. , Jordan-Sciutto K.L.
Biochemistry43:12113-12122(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer."
Padmanabhan B. , Tong K.I. , Ohta T. , Nakamura Y. , Scharlock M. , Ohtsuji M. , Kang M. , Kobayashi A. , Yokoyama S. , Yamamoto M.
Mol. Cell21:689-700(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 309-624 IN COMPLEX WITH NFE2L2;MUTAGENESIS OF 599-SER--ARG-601; 602-SER--VAL-604 AND 605-GLY--VAL-608

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